Employment 1.0 FTE
Gross monthly salary € 2,901 - € 3,707
Organizational unit Faculty of Science
Application deadline 01 June 2025
For the NWO project ‘DBI2’ we are looking for a PhD candidate to study predictive error responses in the auditory cortex. The main goal is to design an experimental approach to distinguish between two alternative theories of predictive coding and processing.
Predictive coding and predictive processing are compelling theories to explain brain function. The idea that the brain continually maintains and updates an internal model of the outside world, and compares the incoming input with the expectations generated by this model, can explain many phenomena including adaptive behaviour and sensory effects such as oddball responses. However, until now there is no consensus on how such predictive coding could be implemented in real neural tissue. Importantly, there are two alternative theories on how error signals in predictive processing could be coded in neural signals: either as (1) top down signals from ‘higher order’ brain areas (hierarchical predictive coding, [2]) or (2) local signals, resulting in membrane potentials reflecting error signals ([3], for a review, see [1]). The goal of the research presented here, under the primary supervision of Dr Zeldenrust, is to design an experimental approach to distinguish between these two theoretical approaches.
Measuring error signals in neural tissue is experimentally challenging. Therefore, a direct exchange between theory and experiment is needed, so that hypotheses and specific predictions about which neurons to record from and stimulate and the results expected can be quickly updated for the design of optimal experiments. The student will work in close collaboration with the Englitz lab, so that there is a direct link between modelling, data analysis and experiment. As a PhD candidate you will use data on oddball paradigms [4,5], which provide the ability to directly observe predictions and distinguish them from prediction errors. The data are a combined approach of widefield imaging of the entire auditory cortex with local and layer-specific imaging using 2-photon recordings in the same animals. To directly test the top-down hypothesis, neurons in subareas of the prefrontal cortex will be transfected with an inhibitory opsin (eNpHR3.0) to modulate their top-down influence.
You will develop a model of the hierarchical interaction between the auditory cortex and the prefrontal cortex, in which error signals are either coded as top-down (theory 1) or local (theory 2). You will use this model to formulate testable predictions, distinguishing theory 1 from theory 2. These predictions will be tested by both analysing existing data from the Englitz lab and formulating new experimental paradigms that are suitable to distinguish between the local and top-down hypothesis.
[1] N’dri, A. W., Gebhardt, W., Teulière, C., Zeldenrust, F., Rao, R. P. N., Triesch, J., & Ororbia, A. (2024). Predictive Coding with Spiking Neural Networks: A Survey (arXiv:2409.05386). arXiv. https://doi.org/10.48550/arXiv.2409.05386
[2] Rao, R. P. N., & Ballard, D. H. (1999). Predictive coding in the visual cortex: A functional interpretation of some extra-classical receptive-field effects. Nature Neuroscience, 2(1), 79–87.
[3] Zeldenrust, F., Gutkin, B., & Denéve, S. (2021). Efficient and robust coding in heterogeneous recurrent networks. PLOS Computational Biology, 17(4), e1008673. https://doi.org/10.1371/journal.pcbi.1008673
[4] Nieto-Diego, J. & Malmierca, M. S. Topographic Distribution of Stimulus-Specific Adaptation across Auditory Cortical Fields in the Anesthetized Rat. (2016) PLOS Biol. 14, e1002397
[5] Lao-Rodríguez, A. B. ... Englitz B, (2023) Neuronal responses to omitted tones in the auditory brain: A neuronal correlate for predictive coding. Sci. Adv. 9, eabq8657
Profile
- You hold an MSc degree in computational neuroscience, mathematics, physics, computer science, AI or a similar computational field.
- You have experience in developing models (preferably in computational neuroscience) and can perform simulations, analytical derivations and advanced data analysis.
- You are a highly motivated, independent, critical, and creative researcher who wants to bridge the gap between real data and abstract theoretical models.
- You are a team player, ready to collaborate in a diverse, multidisciplinary research group.
- You have an excellent command of spoken and written English.
- You have experience in coding (Python and/or Matlab).
We are
You will be appointed at the Biophysics of Neural Computation group, Donders Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour. This vibrant and multidisciplinary institute studies the organisation and function of neural circuits across scales and techniques, from genes and proteins to behaviour, and from in vitro and in vivo experiments to computational modelling. It is an open and international environment, where young scientists from different backgrounds share a fascination for the interaction between brain structure and function. For PhD candidates, there is a lively graduate school and specialised support.
Faculty of Science
The Faculty of Science (FNWI), part of Radboud University, engages in groundbreaking research and excellent education. In doing so, we push the boundaries of scientific knowledge and pass that knowledge on to the next generation.
We seek solutions to major societal challenges, such as cybercrime and climate change and work on major scientific challenges, such as those in the quantum world. At the same time, we prepare our students for careers both within and outside the scientific field.
Currently, more than 1,300 colleagues contribute to research and education, some as researchers and lecturers, others as technical and administrative support officers. The faculty has a strong international character with staff from more than 70 countries. Together, we work in an informal, accessible and welcoming environment, with attention and space for personal and professional development for all.
Radboud University
At Radboud University, we aim to make an impact through our work. We achieve this by conducting groundbreaking research, providing high-quality education, offering excellent support, and fostering collaborations within and outside the university. In doing so, we contribute indispensably to a healthy, free world with equal opportunities for all. To accomplish this, we need even more colleagues who, based on their expertise, are willing to search for answers. We advocate for an inclusive community and welcome employees with diverse backgrounds, cultures, and perspectives. Will you also contribute to making the world a little better? You have a part to play.
If you want to learn more about working at Radboud University, follow our Instagram account and read stories from our colleagues.
We offer
- We will give you a temporary employment contract (1.0 FTE) of 1.5 years, after which your performance will be evaluated. If the evaluation is positive, your contract will be extended by 2.5 years (4-year contract).
- You will receive a starting salary of €2,901 gross per month based on a 38-hour working week, which will increase to €3,707 in the fourth year (salary scale P).
- You will receive an 8% holiday allowance and an 8,3% end-of-year bonus.
- We offer Dual Career Coaching. The Dual Career Coaching assists your partner via support, tools, and resources to improve their chances of independently finding employment in the Netherlands.
- You will receive extra days off. With full-time employment, you can choose between 30 or 41 days of annual leave instead of the statutory 20.
Additional employment conditions
Work and science require good employment practices. Radboud University's primary and secondary employment conditions reflect this. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself. For example, exchange income for extra leave days and receive a reimbursement for your sports membership. In addition, you receive a 34% discount on the sports and cultural activities at Radboud University as an employee. And, of course, we offer a good pension plan. We also give you plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.
Practical information and applying
You can apply only via the button below. Address your letter of application to Fleur Zeldenrust. In the application form, you will find which documents you need to include with your application.
The first interviews will take place on Tuesday 24 June. Any second interview will take place on Tuesday 1 July. You will preferably start your employment on 1 October 2025.
We can imagine you're curious about our application procedure. It describes what you can expect during the application procedure and how we handle your personal data and internal and external candidates.
Application deadline 01 June 2025
We would like to recruit our new colleague ourselves. Acquisition in response to this vacancy will not be appreciated.
Would you like more information?
Dr F. Zeldenrust (Fleur)
[email protected]
