The Laboratory of Bioengineering an Morphogenesis is in the department of Mechanical Engineering at KU Leuven, Belgium and is affiliated with the Leuven Brain Institute (LBI) and the Leuven Institute for Single Cell Omics (LISCO). We collaborate with other groups involved in developmental neurobiology at KU Leuven and internationally. The laboratory is headed by Adrian Ranga and is highly interdisciplinary, seeking to establish a fundamental understanding of neurodevelopmental mechanisms while generating novel technologies and experimental tools (eg. microfluidics, synthetic materials, actuation devices, optogenetic force sensors and actuators) in order to unravel their role in brain development.
Responsibilities
A postdoctoral researcher position is available in the Laboratory of Bioengineering and Morphogenesis at KU Leuven. Our research focuses on understanding the relationship between cell fate, growth and morphogenesis in bioengineered organoid model systems. We are looking for highly motivated, interdisciplinary post-doctoral researchers with a background in neurodevelopment to study the role of active mechanical forces in brain development. The project aims at exploring new and unconventional ways of manipulating and measuring forces during organoid development, to understand mechanisms of symmetry-breaking, growth and patterning in brain development. These approaches will be combined with our established artificial extracellular matrices, optogenetic tools, microfluidic devices, and active force manipulation techniques. We are also especially curious about unconventional modes of regulation of morphogenesis, while using state-of-the art bioengineering technologies and spatial transcriptomics.
The research fits within the scope of a large, multidisciplinary research projects funded by the Allen Institute and FWO to understand how active mechanical forces guide stem cell fate decisions and tissue-scale morphogenesis in brain development. It brings together research groups from the Department of Mechanical Engineering, Leuven Stem Cell Institute (SCIL), Leuven Center for Brain & Disease Research (VIB), Leuven Institute for single Cell Omics (LISCO) and Leuven Brain Institute (LBI). Expertise ranges from molecular biology to cell and matrix mechanobiology, optogenetics, advanced microscopy and spatial transcriptomics.
Profile
We are looking for postdoctoral researchers having recently completed or soon to complete a PhD. Candidates must have PhD degree in developmental biology, with a preference for a background in neuroscience. Good knowledge of English is sufficient for all communications both within and outside the research group.
Offer
Funding for this position is secured for three years (with possibility of extension). The position is available immediately. We offer an international, interdisciplinary and challenging research environment, with many opportunities for collaboration, both at and outside KU Leuven and exposure to cutting-edge technology. KU Leuven offers a competitive salary, including extensive social security. KU Leuven is among the top European universities and a hub for interdisciplinary research at the interface of engineering and biomedical sciences. The city of Leuven offers a historical and vibrant international environment with a rich socio-cultural life.
Interested?
The position is immediately available and will be filled once suitable candidates have been identified. A CV and cover letter indicating why you are interested in the position should be sent to prof. dr. Adrian Ranga, tel.: +32 16 32 59 77, mail: [email protected].
KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.
