Bioinformatician

Do you want to contribute to top quality medical research?

The bioinformatician position is placed in Prof. Richard Rosenquist Brandell’s research group at MMK. The research is focused on applying next-generation sequencing and other omics technologies to explore key molecular events in hematological malignancies and CNS tumours. The group is located at BioClinicum, and includes PhD students, postdoctoral researchers, senior researchers, and bioinformaticians. The group works closely with the Clinical Genetics and Hematology departments at Karolinska University Hospital and Science for Life Laboratory.

Your mission

The research projects focus on analyzing the importance of molecular features for development of hematological malignancies, in particular chronic lymphocytic leukemia (CLL), the most common adult leukemia as well as other lymphomas.

Through in-depth characterization of specific subgroups of CLL/lymphomas we aim to map key molecular events that contribute to the disease pathogenesis at the genome, transcriptome, methylome, and proteome level. In CNS tumours, the focus will be on developing multi-omics analyses of cell-free DNA to improve diagnosis and follow-up by combining targeted gene sequencing, low coverage whole-genome sequencing and methylation analyses with fragmentomics.

Our projects focus on analyzing large-scale short/long-read next-generation sequencing, single-cell, and multi-omics data as well as implementing and testing new technologies. We aim to recruit an independent and motivated person who can set up and maintain workflows by implementing or adapting existing tools.

Ultimately, these efforts are aimed to drive the development of precision cancer medicine. The appointed person will work with molecular biologists, physicians and bioinformaticians, as well as actively participate in national and international collaborative research projects.

Your profile

Applicants should have a PhD in a field related to the position, such as bioinformatics, biotechnology, engineering, physics, or biomedicine. Further requirements are:

• Documented experience in programming and analysis of next-generation sequencing and other omics data in human disease using R and Python.
• In-depth knowledge of best practices in generating reproducible data analysis workflows.
• Experience in handling Linux based servers and familiarity with HPC.
• Experience with package/environment management systems, for example Docker, Singularity and Conda.
• Experience in designing databases is a merit.
• Excellent communication skills and the ability to work both in collaboration with colleagues from different fields as well as independently.
• Experience in handling biological data, preferably human data.

In this recruitment, great emphasis will be placed on personal suitability. 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna

Choose to work at KI – Ten reasons why

Clinical Genetics – Richard Rosenquist Brandell's research group | Karolinska Institutet

Application

Welcome to apply at the latest 2025-04-20

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

1. Richard Rosenquist Brandell, [email protected]

1. Virpi Töhönen, SACO, [email protected]
2. Taher Darreh-Shori, SACO, [email protected]
3. Elisabeth Noren-Krog, OFR, [email protected]