Postdoctoral researcher in neurodegenerative disease mechanisms with focus on Alzheimer disease therapy

Do you want to contribute to top quality medical research?

This position will be located at the KI Campus Solna in BioClinicum, in the group of Associate Professor Lars Tjernberg in collaboration with Professor Bengt Winblad. The ultimate goal of the research in this group is to understand the pathological pathways leading to Alzheimer disease and explore novel therapeutic concepts for Alzheimer disease.

Your mission

This project focuses on the development of potential drugs that target amyloid and tau pathology for AD and other neurodegenerative diseases. We will use multiple methods to develop drug candidates, investigate their biological effects in different cell and mouse models, and validate them in proof-of-concept experiments.

This position involves the evaluation of biological effects of drug candidates. Specifically, the duties include cell culture (mouse embryonic primary neurons and human induced pluripotent stem cells), Western blot, co-immunoprecipitation, immunofluorescence staining, fluorescence microscopy imaging, plasmid manufacturing, cell transfection, live cell Forster Resonance Energy Transfer imaging, drug delivery system development (such as nanoparticles), drug administration, and animal behaviour tests.

We are searching for 1 postdoc. The position is for temporary employment for two years.

Your profile

We are looking for a highly motivated person who is well acquainted with cell biology, biochemistry, or similar topics. Experiences in cell culture, co-immunoprecipitation, immunofluorescence staining, cell transfection or transduction, confocal imaging and drug delivery system development are required. Experiences in drug administration, animal behaviour tests, and plasmid manufacturing are meritorious. Previous experience working with proteolysis targeting chimera, tau, ubiquitin-proteasome system, and electron microscopy is advantageous. Good teamwork skills, ability to work independently, and very good knowledge of English, both written and spoken, are also required.

To be eligible for employment as a postdoctor a phd or a foreign degree deemed to be equivalent to a Swedish phd is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest December 8th 2024.

The application is to be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 540 employees and a revenue 2023 of 530 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

The Division of Neurogeriatrics consists of about 65 employees. The division conducts experimental and translational research related primarily to Alzheimer's disease and other neurodegenerative diseases, but also more general molecular mechanisms with biomedical relevance are studied. The division is mainly located in BioClinicum, KI Campus Solna, and partially in Neo, KI Campus Flemingsberg.

1. Lars Tjernberg, Research Group Leader, 070-3665017
2. Johanna Lundblad, HR, 08-52486835

1. Taher Darreh-Shori, SACO, taher.darreh-shori@ki.se
2. Henry Wölling, SEKO, henry.wolling@ki.se
3. Carina Eklund, OFR, 08-58582665