Computational chemist (Research infrastructure specialist) to CBCS

Do you want to contribute to top quality medical and chemical biology research?

Join our national infrastructure in Chemical Biology as a computational chemist. The position is for one year temporary employment contract.

Karolinska Institutet is one of the leading medical universities in Europe. Through research and education, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine.

The Chemical Biology Consortium Sweden (CBCS) is a Swedish Research Council-funded infrastructure that has been in operation since 2010. Initially comprising two nodes at KI and Umeå University, CBCS was expanded in 2022 with the addition of nodes at Lund, Uppsala, Linköping, and Gothenburg Universities.

As an infrastructure for chemical biology at Science for Life Laboratory's Chemical Biology and Genome Engineering platform, CBCS specializes in identifying bioactive small molecules or chemical tools for all fields of life sciences. We offer collaborative services and guidance in assay development, small-molecule screening, and hit to chemical probe optimization. We are also in the process of establishing additional service offerings in small-molecule profiling, including Cell Painting, and screening in primary and complex disease models. To learn more about CBCS, please visit our website at www.CBCS.se.

What we offer

• An opportunity to work within a state-of-the-art research infrastructure, contributing to high-impact chemical biology and drug discovery projects.
• Access to advanced resources and collaborative networks across disciplines.
• A stimulating environment that supports professional growth and encourages innovative research.

Your mission

Key Responsibilities:

• Collaborate with a multidisciplinary team of researchers on drug discovery projects.
• Provide specialized computational chemistry support tailored to project needs.
• Contribute to the development and implementation of innovative computational methods.

Under the guidance of our senior computational chemist you will provide state of the art computational chemistry methods to a variety of chemical biology projects and perform structure- and ligand based drug design, conformational analysis, and data mining and of course use AI/ML methods when applicable.

Eligibility requirements

To be eligible for an employment as Research Infrastructure Specialist the applicant must have demonstrated research expertise and been awarded a doctorate or a qualification from a foreign higher education institution deemed equivalent to a Swedish degree of doctor. The applicant must also have demonstrated technological and methodological expertise.

Assessment criteria

Required Competencies and Skills

• Computational Expertise: Proficiency in structure- and ligand-based design, conformational analysis, and data mining. Familiarity with AI/ML, AlphaFold and molecular dynamics is a plus.
• Programming Skills: Strong coding abilities in Python, R, and experience with Unix-like operating systems (e.g., Linux). Knowledge of databases and SQL is advantageous.
• Communication: Excellent verbal and written communication skills in English.

Qualifications

• Required: Ph.D. in Chemistry, Computational Chemistry, or a related field.
• Preferred: At least 1 year of relevant research experience in an academic or research institution.

It is particularly meritorious that the applicant has shown

Besides expertise in computational methods mentioned above it is extremly important to have a ”service focused mindset and “Team science” quality to be able to interact within our research infrastructure as well as toward user groups.

It is meritorious that the applicant has shown

Experience from other chemical biology areas or the drug discovery industry.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative, international and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement.

As a national infrastructure hosted by KI we are funded by the National Research Council and the Science for Life laboratory. The later contains a unique setting for national infrastructure in biomolecular science.

Location: SciLifeLab, Solna

Application

We prefer that Your application is written in English, but You can also apply in Swedish. The application must be written in accordance with Karolinska Institutet's merit portfolio for research infrastructure specialist/senior research infrastructure specialist (link).

Welcome to apply at the latest 2024-09-25

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

1. Anna-Lena Gustavsson, 0703965178

1. Anurupa Nagchowdhury, OFR, anurupa.nagchowdhury@ki.se
2. Helin Norberg, SACO, helin.norberg@ki.se