PhD Student (f/m) in the Structural Biology group

The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity. 

Thesis subject: Substrate channeling and structural dynamics in vitamin B6 biosynthesis Substrate channeling and structural dynamics in vitamin B6 biosynthesis probed by high pressure and time-resolved macromolecular crystallography You will join the Structural Biology Group Groups at the ESRF and the University of Southampton to pursue studies in high-pressure macromolecular crystallography to map gas channels in proteins. Specifically, you will investigate ammonia substrate transport through an internal protein channel in the vitamin B6 biosynthetic enzyme Pdx1 from plants, bacteria or from the malaria causing pathogen Plasmodium. You will combine crystallography at cryogenic temperatures with time resolved studies at room temperature, using serial crystallography and spectroscopic techniques.

Further information may be obtained from Christoph Mueller-Dieckmann (phone: +33 (0)4 76 88 28 70, email: muellerd@esrf.fr), Phillipe Carpentier (phone: +33 (0)4 76 88 27 72, email: philippe.carpentier@esrf.fr) or Ivo Tews (phone: ++44 (0)23-8059-4415, email: Ivo.Tews@soton.ac.uk). 

- Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biology, biophysics, chemistry, or physics or a closely related science

- A background in structural biology or biophysical methods is desirable

- Ability to interact within a multi-disciplinary team

- Wide interest in instrumentation, methodology and applied biological research

- Proficiency in English (working language at the ESRF)

The salary will be calculated on the basis of relevant qualifications and professional experience.

Do you recognize yourself in this description? Apply now for your next professional adventure!

What we offer:

- Join an innovative international research institute, with a workforce from 38 different countries

- Collaborate with global experts to advance science and address societal challenges

- Come and live in a vibrant city, in the heart of the Alps, and Europe's Green Capital 2022

- Enjoy a workplace designed to support your quality of life

- Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble For further information on employment terms and conditions, please refer to https://www.esrf.fr/home/Jobs/what-we-offer.html

The ESRF is an equal opportunity employer and encourages applications from disabled persons.