Job type: PhD student
Qualifications: post-graduate, master
Employment type: temporal/contract
Job hours: full time
Employer: EN-ACTI2NG ITN
Locations: Bristol, UK; Leiden, NL; Cologne, DE; Wuerzburg, DE; Freiburg, DE; Viena, AT; Anif, AT; Pamplona, ES; Madrid, ES.
Application URL: http://www.enacti2ng-itn.eu
Application e-mail: firstname.lastname@example.org
Application deadline: May 15, 2017
The EU-funded H2020-Marie Sklodowska Curie Action – Innovative Training Network (H2020-MSCA-ITN) EN-ACTI2NG (grant agreement 721358), with partners in the United Kingdom, The Netherlands, Germany, Austria and Spain, is looking for 10 PhD candidates to work on projects aimed at improving T cell mediated immuno-therapy against cancer by the identification and development of new cancer-specific immune receptors (CARs and TCRs) and enhancing their function by identifying and modifying their molecular mechanism of action. Individual research projects (see hyperlinks below) for the students range from biophysical and microscopic analysis of immune receptors, via molecular modification of their structure and testing their tumor killing capacity in vitro and in vivo to development of microfluidic devices that provide new means of analysis and selection of immune receptor-bearing cells. Each student will have the unique opportunity to experience these complementary approaches within specific secondments in research laboratories, clinics and companies. Extensive training in research-specific skills, career development and a continuous training in communication skills will help the students to become facilitators of transformation of scientific innovation into products with social and economic value.
Qualifications and skills:
We are looking for enthusiastic post-graduate/master students, who either have finished or will finish their master or equivalent degree by Fall 2017, with a background in biology, molecular biology, biochemistry, biophysics, chemistry, engineering, microfluidics or related fields with a good command of English. Students (f/m) from all nationalities can apply but should fulfill certain criteria stipulated by the MSCA-ITN program. See the network’s website (http://www.enacti2ng-itn.eu) for more details on the research project and training program as well as the application procedure and requirements.
- PhD1: CSIC Determination of CD3 domains involved in TCR nanocluster formation to improve T cell sensitivity
- PhD2: UFR The role of novel TCR-CD3 interaction partners for TCR and CAR function
- PhD3: UKK Combinatorial antigen recognition by two tumor-specific CARs with split signaling moieties
- PhD4: LUMC Identification of high affinity TCRs directed against B cell malignancy-associated target antigens
- PhD5: MUW Visualizing and quantitating CAR T-cell antigen recognition at single molecule resolution
- PhD6: TUW Single molecule mobility and protein-protein interactions in CAR T-cells
- PhD7: STRATEC CONS Microfluidic chip development for microscopy-assisted observation and selection of single cells
- PhD8: FIMA Identification of TCR and costimulatory receptor-specific aptamers to generate artificial TCR-signalosome/aptamer scaffolds
- PhD9: UBR Selection of CD8 co-receptor variants for optimization of TCR gene therapy
- PhD10: UWÜ Novel CAR formats with enhanced signaling and tumor recognition properties